Cathey’s Creek Church of Christ is located in the Cathey’s Creek / Isom area of western Maury County. It was known as the Isom Church of Christ. The first sermons preached here were by “Brother Kincade” from Bedford County, and were delivered from a sandbar on Cathey’s Creek in 1818. His listeners were said to have come from a nearyby Presbyterian church. Those who responded to the call of the gospel referred to themselves as the “Christian Church”. Alice Cathey was the first recorded baptism. Meetings were held here in which as many as 100 people were baptized in obedience to the gospel.

In 1820 a log meeting house was built north of Kittrell Cemetery, thus establishing a congregation which is now over 200 years old. In 1843 a second log structure replaced the original. This structure was razed in 1870. A large frame building was then built, which burned around 1893. A smaller meetinghouse replaced this building and was also used as a school. In 1910 the church bought 3 acres of land from Mr. Lucious Morrow for $300 and the present building was built. The Dry Fork Church of Christ congregation aided in the construction of the building.

According to several different references, since 1937 the following repairs and renovations have been completed to the current building.

• 1937 - Electricity was installed (monthly bill was $1.00 per month)
  
• 1940 - Carpet was bought for the auditorium for $71.78
• 1949 - The first Sunday school rooms were added along with the installation of large fans in the back windows, gas heaters, and floor registers.
• 1956 - Two additional classrooms were added.
• 1957 - The present pews were bought for the auditorium for $2,174.00
• 1958 - Restrooms were added in the auditorium.
• 1959 - Sheet rock was placed in the auditorium.
• 1965 - The first public address system was installed. The current foyer was built which included moving the restrooms to the current location.
• 1972 - Three additional classrooms were built.
• 1982 - Ceiling fans were installed in the auditorium. 
• 1986 - Vinyl siding was added to the exterior of the building.
• 2004 - The fellowship hall was built.
• 2006 - A new roof was installed.
• 2007 - The pews were repaired and reupholstered.
• 2012 - A new audio and projector system was installed.